葆明配方可以改善视疲劳和干眼症吗？来看看纽崔莱的临床研究

2025.06.12

为了给您带来安全有效的护眼营养，纽崔莱进行了一项业内领先的研究。纽崔莱健康研究院与上海交通大学附属新华医院等权威机构合作，开展了一项包含360名受试者的随机双盲临床试验，通过这一行业金标准，证明由叶黄素酯、玉米黄质、黑加仑、菊花、枸杞提取物组成的葆明配方，能够显著改善眼酸痛、视力模糊、干眼症、异物感和流泪等视疲劳问题。依托葆明的实验，纽崔莱健康研究院的阚君陶博士在世界营养学顶级期刊The American Journal of Clinical Nutrition（影响因子7.045）发表以下论文。

Kan J, Wang M, Liu Y, et al. A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study[J]. The American Journal of Clinical Nutrition, 2020, 112(2): 334-342.

（点击“下载附件”，下载论文原文及海报）

1. Original Research Communications

2. 一项由多种植物提取物组成的全新配方（纽崔莱葆明配方），改善视疲劳和干眼症的随机、双盲、安慰剂对照研究

3. A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study

4. Juntao Kan, Min Wang, Ying Liu, Hong Zhenheng Gu, and Jun Du

5. Nutrilite Health Institute, Shanghai, China; Department of Epidemiology, Department of Medicing,Vanderbilt, Fudan University, Shanghai, China; College of Bio-Ophthalmology, Xinhua Hospital, Shanghai, China

6. ABSTRACT

7. Background: With the frequent use of , eye fatigue is becoming more common globally. nutritional strategy is needed to prevent the aggravation of symptoms.

8. Objectives: The objective was to evaluate the protective effect of a novel botanical combination of lutein ester, zeaxanthin, and extracts of blackcurrant, chrysanthemum, and goji berry on adults with eye fatigue in a randomized, double-blind, placebo-controlled clinical trial.

9. Methods: We randomly allocated 360 participants into 4 groups to receive placebo and 3 doses of our formula (chewable tablets, containing 6 mg, 10 mg, or 14 mg of lutein) once daily for 90 d. Each participant had 3 visits at baseline (V1), 45 d (V2), and 90 d (V3) during the study.

10. Results: Intervention with the formula improved individual scores of eye fatigue symptoms, including eye soreness, blurred vision, dry eye, foreign body sensation, and tearing. Compared with placebo, the formula at all 3 doses significantly decreased the total score of eye fatigue symptoms and increased the visuosensory persistence time at both V2 and V3. According to the Schirmer test, both 10-mg and 14-mg lutein formula groups had improved tear pared with the placebo. The keratograph results first tear break-up time, average tear break-up time, height were significantly increased after formula at all 3 doses significantly increased optical density at V2 and V3 compared with placebo. Optical coherence tomography showed no in retinal thickness and retinal volume across all groups at both visits.

11. Conclusions: Our botanical formula improves eye fatigue, dry eye, and macular function without changing the retinal structure, and thus it could serve as an effective nutritional strategy in improving eye fatigue without causing serious side effects. [Clinical Trial Registry: chictr.org.cn (ChiCTR1800018987). Am J Clin Nutr 2020;00:1–9.

13. 该论文发表于国际营养学顶级期刊《美国临床营养杂志》2020年112卷第2期整篇论文请去安利头条App下载专区下载

14.目的:通过随机、双盲、安慰剂对照的临床试验，评估由叶黄素酯、玉米黄质、黑加仑、菊花、枸杞提取物组成的全新配方，对成人视疲劳的保护作用。

实验:我们将 360 名受试者随机分为四组，每天服用安慰剂或三个剂量的配方(含 6mg、10 mg 或 14mg 叶黄素)持续 90 天。在研究期间，每个受试者在第1天、第 45 天和第 90 天有三次访视。

15.结论:在不改变视网膜结构的情况下，该植物配方改善了视疲劳、干眼症和黄斑功能，同时也没有发现副作用，可以作为一种有效的营养策略。

16. Introduction,Eye fatigue, also defined as asthenopia, is a comon conditionin both adults and children. A variety of factors can causeeye fatigue, including eye faclers(refractive and muscular),psychological factors, and environmental factors(l_4). Inparticular, the grwing use of video display units (VDUs). suchas compulers, mobile phones, and tablets,has inereased theglobat prevalence of eye fatigue at different stages of life (5,6). In Chinese college students, the prevalenee of eye fatigue is

17.This study was funded by the National Key R&D Program of China(2018YFC1706800),Nutrition Research Foundation of Chinese NutritionSociety (CNS-DSM2018A35), and Innovation Funding of Amway (China)R&D Center, The study design, implementation, analysis, and interpretation

18.mai. Eric.du @amway.com).

Abbreviations used: AMD, age-related macular degeneration: BUT. tearbreak-up time; CFDA, China Feed and Drug Administration; HFP, hete.rochromatic flieker photometry; MPOD, macular pigment optical densitye€T, optical coherence tomography; ST, Schirmer test; TCM, traditionalChinese medicine: VDU. video display unit.Received January 14,2020. Accepted for publication May 15. 2020.First published online 0,2020: doi: https://doi.org/10.1093/ajcn/ngaa139

1. Original Research Communications

2. 一项由多种植物提取物组成的全新配方(纽崔莱葆明配方)，改善视疲劳和干眼症的随机、双盲、安慰剂对照研究

3. A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study

4. Juntao Kan, Min Wang, Ying Liu, Hong Zhiheng Gu, and Jun Du

5. Nutrilite Health Institute, Shanghai, China; Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China; College of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

6. ABSTRACT

7. Background: With the frequent use of video display units (VDUs), such as computers, mobile phones, and tablets, eye fatigue is becoming more common globally.

10. Results: Intervention with the formula improved individual scores of eye fatigue symptoms, including eye soreness, blurred vision, dry eye, foreign body sensation, and tearing. Compared with placebo, the formula at all 3 doses significantly decreased the total score of eye fatigue symptoms and increased the visuosgnostic persistence time at both V2 and V3. According to the Schirmer test, both 10-mg and 14-mg lutein formula groups had improved tear film compared with the placebo. The keratography results showed that first tear break-up time, average tear break-up time, and height were significantly increased after formulating the formula at all 3 doses significantly increased optical density at V2 and V3 compared with placebo. Optical coherence tomography showed no significant change in retinal thickness and retinal volume across all groups at both visits.

13. 目的：通过随机、双盲、安慰剂对照的临床试验，评估由叶黄素酯、玉米黄质、黑加仑、菊花、枸杞提取物组成的全新配方，对成人视疲劳的保护作用。

14. 实验：我们将360名受试者随机分为四组，每天服用安慰剂或三个剂量的配方（含6mg、10mg或14mg叶黄素），持续90天。在研究期间，每个受试者在第1天、第45天和第90天有三次访视。

15. 结论：在不改变视网膜结构的情况下，该植物配方改善了视疲劳、干眼症和黄斑功能，同时也没有发现副作用，可以作为一种有效的营养策略。

16. 该论文发表于国际营养学顶级期刊《美国临床营养杂志》2020 年 112 卷第 2 期

17. 整篇论文请去安利头条 App—下载专区下载